How Generalizable Are Randomized Controlled Trials (RCTs) in Staphylococcus aureus Bacteremia? A Description of the Mortality Gap Between RCTs and Observational Studies

Anthony D Bai,Carson K L Lo,Adam S Komorowski,Mallika Suresh,Kevin Guo,Akhil Garg,Pranav Tandon,Julien Senecal,Olivier Del Corpo,Isabella Stefanova,Clare Fogarty,Guillaume Butler-Laporte,Emily G McDonald,Matthew P Cheng,Andrew M Morris,Mark Loeb,Todd C Lee

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

In Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than observational studies. Stringent eligibility criteria and omission of early deaths in RCTs contribute to this mortality gap. Clinicians should acknowledge the possibility of a lower treatment effect when applying RCT results to bedside care.

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关键词

Staphylococcus aureus, bacteremia, mortality, trials

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