Preoperative Accelerated Hyperfractionated Whole-Breast Radiation as Treatment for Secondary Angiosarcoma of the Breast After Prior Accelerated Hypofractionated Whole-Breast Radiation Therapy: A Case Report and Review of the Literature

Sarcomas of the breast comprise <1% of all breast malignancies and are histologically heterogenous, nonepithelial tumors that arise from the connective tissue of the breast.1,2 Development of breast sarcomas can be de novo or related to prior radiation therapy.3 Radiation-induced malignancies are identified using the Cahan criteria, requiring that the secondary tumor is of a sarcomatous nature, different from the original tumor histology, that the development occurs in an irradiated area, and that there is a prolonged latency period between the 2 malignancies.