Conformational dynamics promotes disordered regions from function-dispensable to essential in evolved site-specific DNA recombinases

Carla Guillén-Pingarrón,Pedro M. Guillem-Gloria,Anjali Soni,Gloria Ruiz-Gómez,Martina Augsburg,Frank Buchholz,Massimiliano Anselmi,M. Teresa Pisabarro

Computational and Structural Biotechnology Journal（2022）

Cited 3|Views11

No score

Abstract

•New functional regions emerging in evolution of DNA site-specific recombinase tails.•Transient structural nucleation promotes function-dispensable regions to essential.•Molecular dynamics reveals conformational diversity and its functional implications.•Evolved disordered molecular mechanisms of N-term tails for protein stability.•Structural disorder-based link between protein evolution, stability and function.

Translated text

Key words

Intrinsically disordered protein regions,site-specific DNA recombinase,Evolution,Molecular dynamics,Structural disorder,Thermodynamic stability,AI-based folding

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined