Bone marrow mesenchymal stem cells modified with heme oxygenase-1 alleviate rejection of donation after circulatory death liver transplantation by inhibiting dendritic cell maturation in rats

Longlong Wu,Huan Cao,Xuan Tian,Weiping Zheng,Mengshu Yuan,Xiang Li,Xiaorong Tian,Yuxin Wang,Hongli Song

International Immunopharmacology（2022）

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摘要

•Using the NMP system to inject HO-1/BMMSCs into DCD livers was an effective method.•Overexpression of HO-1 prolonged BMMSC survival in the graft.•Overexpression of HO-1 enhanced BMMSC immunomodulatory ability.•HO-1/BMMSCs alleviated acute rejection by inhibiting the maturation of DCs.•ERK1/2 and p38 phosphorylation are involved in DC mature regulation by HO-1/BMMSCs.

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关键词

Bone marrow mesenchymal stem cells,Liver transplantation,Dendritic cells,Acute rejection,Normothermic machine perfusion

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