Blunted cerebral oxygenation during exercise in systemic lupus erythematosus patients.

Nikolaos Koletsos,Konstantina Dipla,Areti Triantafyllou,Antonios Lazaridis,Nikolaos G Papadopoulos,Panagiotis Dolgyras,Eleni Gavriilaki,Panagiota Anyfanti,Andreas Zafeiridis,Evaggelia-Evdoxia Koravou,Spyros Aslanidis,Stella Douma,Eugenia Gkaliagkousi

Clinical and experimental rheumatology（2023）

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摘要

To our knowledge, this is the first study to evaluate cerebral oxygenation during exercise using NIRS in SLE patients compared to age-matched controls. Our data show that SLE patients even without overt neuropsychiatric manifestations exhibit a blunted increase in cerebral-O2Hb during a submaximal exercise stimulus. Examining brain oxygenation during a simple exercise task may assist in identifying patients with early alterations in cerebral function.

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关键词

systemic lupus erythematosus,brain oxygenation,near-infrared-spectroscopy,microcirculation,exercise,autoimmune disease

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