Synthesis of Tetrahydrofuro[2,3-d]-oxazoles and Oxazoles by Hypervalent Iodine (III)-Promoted [2+2+1] Annulation
CHEMICAL & PHARMACEUTICAL BULLETIN(2022)
Abstract
Reaction of a hypervalent iodine reagent with bistriflimide efficiently promotes three-component regioselective cyclization of tetrahydrofuro[2,3-d]oxazoles and oxazoles from homopropargyl alcohols bearing a phenyl group, with different substituents on the aryl alkyne compounds affecting the selectivity of the resulting product. Utilizing the hydroxyethyl oxazole derivatives obtained in this research could aid in the development of various peroxisome proliferator-activated receptor agonist derivatives.
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Key words
hypervalent iodine, [2+2+1] annulation, tetrahydrofuro[2,3-d]oxazole, oxazole
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