Increased Brain Volume A Novel Biomarker of Neurodegeneration?

Among patients with Alzheimer disease (AD), a common neuropathologic finding is cerebral amyloid angiopathy (CAA).(1) The main hallmarks of CAA are cerebral microbleeds (CMBs) and cortical superficial siderosis (cSS).(1) Both CMBs and CAA correlate with progressive cognitive impairment in patients with AD.(2,3) This provides further evidence for the dual nature of neurodegenerative diseases such as AD, sustained by the interplay between neurovascular and neurodegenerative processes.(4)