Anti-Cancer Effects of Preoperative Chemotherapy for Gastric Carcinoma — The Relationship Between Histopathological Effects and Thymidilate Synthetase Inhibition Rate (TSIR)

In a previous study, the prognosis of positive histopathological effect cases with preoperative chemotherapy was significantly better than negative histopathological effect cases in advanced gastric cancer. This time, we investigated the relationship between the histopathological effects and Thymidilate Synthetase Inhibition Rate (TSIR). Object were 14 resected gastric cancer with preoperative chemotherapy of 5-Fu 300 mg/day for 14 days by oral administration. FdUMP, TS-free and TS-total were measured by the tumor sample and TSIR value was calculated. TSIR value were distributed from 0% to 90.7%, averaged 46.9%. TSIR value of the cases with positive histopathological effect indicated 70.5%, TSIR value without histopathological effect was 23.5%.