Circulation of an Artemisinin-Resistant Malaria Lineage in a Traveler Returning from East Africa to France

Romain Coppée,Justine Bailly,Véronique Sarrasin,Bertin Vianou,Boris Enock Zinsou, Edith Mazars,Hugues Georges,Samia Hamane,Rose Anne Lavergne,Eric Dannaoui,Betty Balikagala,Naoyuki Fukuda,Emmanuel I Odongo-Aginya,Toshihiro Mita,Sandrine Houzé,Jérôme Clain

CLINICAL INFECTIOUS DISEASES（2022）

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摘要

A returned traveler to Uganda presented with a Plasmodium falciparum kelch13 A675V mutant infection that exhibited delayed clearance under artesunate therapy. Parasites were genetically related to recently reported Ugandan artemisinin-resistant A675V parasites. Adequate malaria prevention measures and clinical and genotypic surveillance are important tools to avoid and track artemisinin resistance.

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Plasmodium falciparum, kelch13, artemisinin resistance, East Africa, whole-genome sequencing

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