Characterization and quantification of ginsenosides from the root of Panax quinquefolius L. by integrating untargeted metabolites and targeted analysis using UPLC-Triple TOF-MS coupled with UFLC-ESI-MS/MS

•UPLC-Triple TOF-MS SWATH was used for the first time for untargeted analysis of RPQ.•225 ginsenoside metabolites were identified in RPQ.•39 ginsenoside markers in RPQ were analysed using UFLC-ESI-MS/MS.•Sources and American ginseng plant age affected RPQ product quality.