Autoantibody-Mediated Changes in Platelets Sialic Pattern: Potential Impact on Platelet Functionality and Lifespan in Immune Thrombocytopenia

Introduction Immune thrombocytopenia (ITP) is a bleeding disorder mediated by autoantibodies (AAbs) that are targeting different glycoproteins (GPs) on the platelet (PLT) surface. Desialylation, the loss of sialic acid from PLT GPs, has been reported to contribute to the increased PLT destruction in ITP. In this work, we investigated the impact of AAb-mediated desialylation on the function as well as apoptotic status of human platelets.