Targeting a ceramide double bond improves insulin resistance and hepatic steatosis
Yearbook of Paediatric Endocrinology(2020)
Abstract
By genetically engineering mice, the authors deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved double bond into the backbone of ceramides. Ablation of DES1 from whole animals or tissue-specific deletion in the liver and/or adipose tissue resolved hepatic steatosis and insulin resistance in mice caused by leptin deficiency or obesogenic diets
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Key words
Hepatic Steatosis,Lipid Dysregulation
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