Functional properties of lymphocyte surface in the development of lymphoproliferative diseases in the blood system

Changes in lymphocyte functional properties due to conformational rearrangements of cytoskeletal elements accompany lymphoproliferative diseases. The aim of the work is to study the functional properties of the lymphocyte surface in normal and in the development of acute lymphoblastic leukemia at different stages of the disease course. Materials and methods. In order to achieve this goal, the experiment used blood of patients with acute lymphoblastic leukemia, as a comparison group - blood of healthy people. Blood preparations were scanned on an atomic force microscope in a power spectroscopy mode. Results. New data on the functional properties of normal and tumor lymphocytes were obtained as a result of the study. We found a decrease in Jung's modulus in the group of patients with acute lymphoblastic leukemia at the stage of primary diagnosis at 53% (p < 0.05), at the stage of treatment - at 33% (p < 0.05) and relapse - at 38% (p < 0.05) compared to control. The strength of adhesion in the cell-cell system increased in all examined groups of patients. Conclusion. Obtained data is important for studying mechanisms to maintain immune status in leukemia patients.