Induced pluripotent stem cells in periodontal regeneration - Narrative review

Purpose: Periodontal disease is a severe infection caused by inadequate oral hygiene, resulting in tooth loss due to the bone destruction that supports the teeth. “Induced pluripotent stem cells” (iPSCs or iPS cells) is a sort of pluripotent stem cell that can be acquired out of adult somatic cells like peripheral blood mononuclear cells (PBMCs) or skin fibroblasts through inducing genetic reprogramming genes (Klf4, Oct4, c-Myc, and Sox2). Materials and Methods: This narrative review shows periodontal regeneration and bone regeneration using iPSCs and also highlights the drawbacks and challenges towards the future using iPSCs. Results and Discussion: Recent studies have shown greater regeneration when combination of iPSCs and enamel matrix derivates (EMD™) inserted into treatment of periodontal and bone defects. Conclusions: IPSC is a good alternative cell source in periodontal regeneration.