VP15.15: Cardiac cycle time‐related parameters to assess fetal cardiac function in high‐risk fetuses

To explore the potential clinical utility of cardiac cycle time-related pulsed Doppler parameters-filling time fraction (FTF) and ejection time fraction (ETF) in selected high risk fetuses. 54 fetuses were included in our study: 9 pairs of monochorionic twins with stage 3–4 Twin–twin transfusion syndrome (TTTS), 16 aortic stenosis (AoS) and 20 aortic coarctation (CoA). Pulsed Doppler was adjusted to better visualise the opening and closure clicks of the valves (figure 1). Left (LV) and right (RV) ventricular inflow and outflow tracings were obtained to calculate FTF ([filling time/cycle time]*100), and ETF (ejection time[cycle time]*100). Z-scores were calculated using normograms constructed according to heart rate and gestational age. Most recipients (6/9 cases) showed LV and/or RV FTF below the 5th centile and preserved ETF. Donors presented no alterations. AoS was associated with decreased LV FTF in 62.5% of cases (10/16), which was more pronounced in the group of fetuses with univentricular (UV) outcome (biventricular (BV) 5/11, 45.5% vs. UV 5/5, 100%). On the contrary, ETF was increased in 9/16 (56.3%) in the AoS cases with BV outcome (BV 7/11 (63.7%) vs. UV 2/5, 40%). Finally, most fetuses with CoA showed normal FTF and EFT in both ventricles reflecting different pathophysiology from AoS. Cardiac cycle time-related pulsed Doppler parameters show different patterns in in TTTS, AoS and CoA. Future studies are needed to confirm our findings and explore the utility of FTF and ETF in other pathological conditions. Supporting information can be found in the online version of this abstract Relative wall thickness - Left ventricle (LV) - Right ventricle (RV) LV: 1.02 (0.71 - 1.16) RV: 0.95 (0.76 - 1.13) LV: 0.80 (0.68 - 1.01) RV: 0.68 (0.57 - 0.76) LV:0.65(0.59-0.90) RV:0.62(0.57-0.76) 0.056 0.001* 0.021* < 0.001* 0.150 0.135 Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.