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Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel “Dual-Soft” PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis

Jens Larsen,Maja Lambert,Henrik Pettersson,Thomas Vifian,Mogens Larsen,Anna Ollerstam,Pontus Hegardt, Cecilia Eskilsson, Steen Laursen,Anders Soehoel,Tine Skak-Nielsen, Lene M. Hansen, Nina Ø. Knudsen,Stefan Eirefelt,Morten D. Sørensen, Tatiana G. Stilou,Simon F. Nielsen

Journal of Medicinal Chemistry（2020）

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