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Anti-GnRH Neutralizing Antibodies Produce Testosterone Ablation and Tumor Shrinkage in Prostate Cancer Models

Jesús A. Junco,Franklin Fuentes,Lesvia Calzada,Eddy Bover,Eulogio Pimentel,Yovisleidis López,Roberto Basulto,Hilda Garay,Osvaldo Reyes,Angel Cid-Arregui,Maria D. Castro, Rafael Martínez,Niurka Arteaga,Ana Campal,Ayni Rodríguez,Andrés Serradelo, Eduardo Hernández, Mirialis Arias, Raúl González,Matilde López,Gisell Bebert,Gerardo Guillén

Journal of Cancer Science and Clinical Therapeutics（2020）

Cited 1|Views6
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Abstract
Background: Vaccines based on modified GnRH peptide variants can be an alternative treatment for advanced prostate cancer. However, the efficacy of the GnRH-based vaccine variants has been limited by their insufficient immunogenicity.
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Key words
prostate cancer,testosterone ablation,neutralizing antibodies,anti-gnrh
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