Formulation and Ex-vivo Evaluation of Transdermal Patches of Glipizide using the Penetration Enhancer Buchanania- Lanzan (Spreng) Seed Oil

The aim of the present work was to evaluate the permeation enhancement properties of Buchanania lanzan spreng seed oil. Ethyl cellulose transdermal patches of Glipizide using some essential oils as penetration enhancers were developed. Effect of drug loading and penetration enhancers on the in vitro permeation of drug through rat skin was investigated. Incorporation of essential oils enhanced the moisture content, moisture uptake capacity and permeation of Glipizide across skin barriers. Among the penetration enhancers used, Buchanania lanzan spreng seed oil found to be most effective. Stability as well FTIR and DSC studies did not show any Interaction/degradation of the drug. It was concluded that stable and effective Glipizide transdermal patches can be prepared using essential oils as penetration enhancers. Further it was also concludes that the seed oil can be used in permeation enhancement of various types of tropical preparation.