The TCM therapy of spleen-strengthening and dampness-removing and non-alcoholic fatty liver

Nonalcoholic fatty liver disease (NAFLD) is an import risk factor for peoples’ health, which can lead to diabetes mellitus, coronary heart disease and stroke. The prevalence of NAFLD is increasing rapidly in China, increasing the national healthy economic burden. Microsome triglyceride transfer protein (MTP) is a key enzyme for liver lipids transport, and the increase in MTP promoter methylation plays an import roll in liver lipid deposition. Traditional Chinese medicine believes that “spleen Qi transfers essence”, and MTP may be one of the substance of “spleen Qi transfers essence”. Clinical studies have shown that the spleen-strengthening and dampness-removing therapy has a good effect in the treatment of NAFLD. By reviewing related articles, this paper points out that the therapy of Spleen-strengthening and dampness-removing can improve NAFLD by regulating MTP promoter methylation, increasing the level of hepatic MTP, promoting the outflow of liver lipids.