Bradykinin regulates plasmin-induced endothelial Ca<sup>2+</sup> response in PARs dependent pathway

Background: Plasmin is a fibrinolytic factor and a serine protease that activates protease-activated receptors (PARs) to produce endothelium-derived relaxing factors (EDRFs) such as nitric oxide and prostacyclin. Nitric oxide and prostacyclin production is regulated, at least in part, by the intracellular Ca2+ concentration in various blood vessel types. Bradykinin and plasmin stimulate vascular endothelial cells and work simultaneously in pathophysiological conditions such as thrombosis and inflammation. We explored the interactions between bradykinin and plasmin in the endothelial Ca2+response