Status epilepticus-induced changes in astrocytic Kir4.1 channel expression in pilocarpine model of temporal lobe epilepsy

Higor A. Iha,Takahiro Mukai, Haruna Imaura,Takayuki Nakamura, Satoko Yamashita,Tatsuya Yamamoto,Saki Shimizu,Kazuaki Sato,Akio Ikeda,Yukihiro Ohno

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2018）

Cited 0|Views3

No score

Abstract

Background: Astrocytic inwardly rectifying potassium (Kir) 4.1 channels are responsible for spatial K+ buffering in synaptic clefts by removing excessive K+, which consequently controls neural excitability. To evaluate the modulatory role of Kir4.1 channels in the development of temporal lobe epilepsy (TLE), we assessed the expressional changes in astrocytic Kir4.1 channels following pilocarpine (PILO)-induced status epileptics (SE) in PILO-TLE rats.

Translated text

Key words

temporal lobe epilepsy,pilocarpine model,epilepticus-induced

AI Read Science

Must-Reading Tree

Example

Generate MRT to find the research sequence of this paper

Chat Paper

Summary is being generated by the instructions you defined