Investigating the effect of tizanadine in depression using antidepressant screening test in mice

Background: Tizanadin is been evaluated as a novel drug candidate for treating depression using Mice. The various limitations of presently available antidepressants stress the need for improve pharmacotherapy intervention. Tizanadin may be a potent new therapeutic option for depression because studies have shown that Alpha 2 adrenergic receptor activation contributes to the antidepressants effect of Noradrenalin reuptake inhibitors like Desipramine, suggesting the possibility of Tizanadin as a good antidepressant.