Role of renin-angiotensin system inhibitors in attenuation of dexamethasone-induced ECM remodeling in human trabecular meshwork cells

Background: Trabecular meshwork remodeling leads to aqueous humor outflow resistance and increases intraocular pressure, one of the major risk factor of glaucoma. Renin angiotensin system (RAS) inhibitors are known to attenuate tissue remodeling in cardiovascular system, however their effects on human trabecular meshwork (HTM) are poorly understood.