Systemic inflammation in primary hypercholesterolemia results in platelet and leukocyte activation and their enhanced endothelial adhesiveness

Background: Primary hypercholesterolemia (PH) is an autosomal dominant monogenic disease of lipoproteic metabolism characterized by a marked increase of low-density lipoprotein (LDL) levels. A low grade of systemic inflammation is often associated with PH and systemic inflammation is involved in the development of premature coronary diseases associated with the atherosclerotic process.