Comparison Of The Concentrations Of Cyclosporine-A Containing Ophthalmic Microemulsion And Nanosuspansion Formulations In Aqueous Humor In The Rabbit Experiment Model

Background: Dry eye, which is a result of decrease in the production of tears or an increase in evaporation, is a disease that causes complaints of foreign body sensation and pain. Even if the pathophysiology of the disease is not fully understood, it is thought to be an inflammation mediated by immunity. It is thought that the ophthalmic emulsion of the immunomodulator cyclosporin A has a positive effect on the underlying inflammatory pathology. However, it accumulates more in extraocular tissues and drug absorption to intraocular tissues is limited. Nanosuspension is a drug formulation that aims to increase bioavailability by producing drug particles in submicron dimensions. In this study, we aimed to compare the concentrations of Restasis and Depores, the Cyclosporin-A microemulsion formulations, which are bioequivalent in our country, to Cyclosporin-A nanosuspension formulation with particle size less than 500 nm in aqueous humor.