Angiogenesis: Mechanical Cues Regulating Proangiogenic Potential of Human Mesenchymal Stem Cells through YAP‐Mediated Mechanosensing (Small 25/2020)

In article number 2001837, Junmin Lee, Ali Khademhosseini, and co-workers develop a bioreactor-based platform to investigate the effect of human mesenchymal stem cell (hMSC) culture microenvironments including matrix rigidity and dynamic mechanical compression on their secretion level of pro-angiogenic factors. It is demonstrated that these mechanical cues regulate pro-angiogenic potential of hMSCs through yes-associated protein (YAP)-mediated mechanosensing.