Sydney Brenner. 13 January 1927—5 April 2019

From modest beginnings Sydney became an extraordinarily influential and accomplished molecular biologist. His critical knowledge of, and insights into, key scientific problems were legendary. His irrepressible personality, acerbic wit and ebullient talks inspired a generation of young biologists. He made seminal discoveries in how genetic information is used for protein synthesis, and established Caenorhabditis elegans as one of the foremost model organisms for the study of development and neural function. He also pioneered techniques for genome analysis and was instrumental in establishing several outstanding centres of biological research around the world.