Role of Dna Repair Pathways in Aging- A Review

Aging is a process where decrease of function occurs followed by DNA damage.DNA replication or transcription are affected because of structural damage to DNA, which leads to alteration or elimination of fundamental cellular process.To overcome this defect cell develop certain repair mechanisms.They are Base Excision Repair, mismatch repair, nucleotide excision repair, and double-strand break repair, homologous recombination, non-homologous end joining.Cancer cells can have increased rate of proliferation capacity, reduced apoptosis and increased capacity to invade basement membrane and metastasize.Because of genomic instability of cancer cell they easily break and reform chromosome and stimulate fusion of new oncogene and tumor suppressor gene are inactivated.To overcome this cancer cells should have capacity to withstand DNA damage.