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The role of cytokines in redox-dependent regulation of apoptosis

O. Ye. Chechina,A. K. Biktasova, Ye. V. Sazonova,O. B. Zhukova,T. S. Prokhorenko,I. V. Krat,N. Yu. Chasovskikh,V. V. Novitsky,N. V. Ryazantseva

Bulletin of Siberian Medicine（2009）

Cited 6|Views1
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Abstract
Research of influence of recombinant tumor necrosis factor alpha, interleukin-2 and interleukin-4 in vitro on the apoptosis of lymphocytes is performed. It is revealed that a proapoptotic effect of these cytokines is dose-dependent and is realized with the assistance of reactive oxygen species and mitochondrias.
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Key words
lymphocyte,cytokines,apoptosis,reactive oxygen species,mitochondria
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