Identification of Novel Determinants of Neutralization Epitope Shielding for Hepatitis C Virus in Vitro

Garazi Peña Alzua,Anne Finne Pihl,Anna Falden Offersgaard,Rodrigo Velázquez-Moctezuma,Elias Honeroed Augestad,Ulrik Fahnøe, Christian Kjaerulff Mathiesen,Mansun Law,Jannick Prentoe,Jens Bukh,Judith Margarete Gottwein

Viruses 2020—Novel Concepts in Virology（2020）

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摘要

Epitope shielding is suggested as an important mechanism mediating the escape of hepatitis C virus (HCV) from host-neutralizing antibodies (nAb). [...]

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关键词

hepatitis C virus,hepatitis,neutralizing antibodies,viral evolution,epitope shielding,vaccine development

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