S133. diagnosed speech, scholastic and motor disorders as predictors for non-affective psychoses

Abstract Background Premorbid cognitive impairments are associated with schizophrenia, but little is known about the risk of developing psychoses among children with diagnosed speech, scholastic and motor disorders. Our aim was to study if children diagnosed with these are at increased risk of non-affective psychoses in adolescence and early adulthood. Methods We identified all children born 1996–2001 that were diagnosed with a speech disorder (ICD-10 code F80), scholastic disorder (F81), motor disorder (F82) or mixed developmental disorder (F83) before age 15 in outpatient and inpatient specialized services in Finland by using nationwide registers (n=17,038). A control cohort of children without these disorders was identified (n=63,745). The outcome was non-affective psychoses (F20-F29) diagnosed between age 15 years and the end of year 2017 (maximum age at end of follow-up: 16.0–21.9 years). We used Cox regression to study the association between speech, scholastic and motor disorders and psychoses and adjusted for sex, urbanicity and comorbid depression and conduct disorders. Results A total of 216 and 251 subjects were diagnosed with non-affective psychoses during follow-up in the cohort of speech, scholastic and motor disorders and the control-cohort, respectively. The cumulative incidence of psychoses from age 15.0 to 21.9 years was 2.4 % (95% confidence interval [CI] 2.0 - 2.8 %) in the cohort of speech, scholastic and motor disorders compared to 0.8 % (95% CI 0.7 % - 1.0 %) in the control-cohort (adjusted hazard ratio [aHR] 2.6, 95% CI 2.2 - 3.2). When stratified by a pure or a combination of at least two speech, scholastic and motor disorders, all categories were significantly associated with psychoses with the highest HR for motor disorders (aHR 3.6, 95% CI 2.0 - 6.4), followed by the combination of different speech, scholastic and motor disorders (3.3, 2.4 - 4.4), pure scholastic disorders (2.4, 1.5 - 3.7) and pure speech disorders (1.7, 1.2 - 2.6). Discussion Non-affective psychoses in late adolescence and early adulthood are associated with speech, scholastic and motor disorders diagnosed in childhood, in particular motor development disorders.