Network pharmacology-based prediction of potential targets of ethnic medicine Blumea balsamifera (L.) DC acting on anti-infammatory effect

Journal of Physics: Conference Series(2020)

Cited 0|Views2
No score
Abstract
Abstract Blumea balsamifera (L.) DC is an ethnic medicine with a significant anti-inflammatory effect. At present, there were many reports on the anti-inflammatory efficacy of B. balsamifera, but the mechanism of its is rarely reported. Therefore, the method of network pharmacology has been adopted in this paper to predict the molecular mechanism of the anti-inflammatory effect of B. balsamifera. The active chemical constituents of B. balsamifera were screened by reference to the literature, TCMSP and TCMID. A target data set of active chemical components was established by traditional chinese medicine target, TCMSP and BATMAN-TCM database. The target of the active ingredients were introduced into the HIT and TTD to establish a potential target data set of the B. balsamifera active ingredients. A OMIM was used to screen for inflammation-related genes and protein targets to establish an inflammatory target dataset. The complex network map of “active ingredient-target-disease” was constructed using Cytoscape3.6.1 software. A PPI analysis database was used to construct a protein interaction network of B. balsamifera component targets and inflammatory targets. GO functional and KEGG pathway enrichment analysis were performed by the biological information annotation database. As a result, 12 active chemical components in B. balsamifera were screened. The corresponding target of 724 active compounds were retrieved. There are 33 signaling pathways and 28 biological processes that were directly or indirectly related to the anti-inflammatory effects of B. balsamifera. Through enrichment analysis, the main signaling pathways of B. balsamifera include TNF signaling pathway, Hepatitis B, Toll-like receptor signaling pathway, NF-kappa B signaling pathway, etc. Finally, Network pharmacology provides new ideas and methods for the study of the anti-inflammatory mechanism of B. balsamifera.
More
Translated text
Key words
ethnic medicine blumea balsamifera,pharmacology-based,anti-infammatory
AI Read Science
Must-Reading Tree
Example
Generate MRT to find the research sequence of this paper
Chat Paper
Summary is being generated by the instructions you defined