Search for preventive drugs against oxaliplatin-induced peripheral neuropathy through drug repositioning

Takahiro Niimura,Yoshito Zamami,Takehiro Kawashiri,Mitsuhiro Goda,Naoto Okada, Masahumi Kayano,Toshihiro Koyama,Masaki Imanishi,Kenshi Takechi,Masayuki Chuma,Yuya Horinouchi,Yuki Izawa-Ishizawa,Yasumasa Ikeda,Daisuke Kobayashi,Takao Shimazoe,Keisuke Ishizawa

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2019）

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摘要

Background: Oxaliplatin causes oxaliplatin-induced peripheral neuropathy (OIPN). Because OIPN reduces patients' quality of life (QOL), the development of preventive agents against OIPN is an important area of research. In this study, we searched for preventive drugs against OIPN by drug repositioning, using large-scale medical data, and experimentally validated the findings with neuron-like cells and OIPN rat models.

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preventive drugs,oxaliplatin-induced

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