Fermented ginseng suppresses AITC-induced nocifensive behavior

Panax ginseng is one of the component of herbal medicine and widely used in Asian countries. Ginsenosides is principal ingredient of Panax ginseng and has multiple effects such as anti-pain, anti-stress and hepatoprotective action. Ginsenoide Rb1 is metabolized to the Compound K (CK) by microflora in the intestine, and CK has stronger physiological activity than Rb1. In this experiment, we prepared two type of ginsengs, fermented ginseng (FG) which contain high amount of CK and non-fermented ginseng (NFG). Here we studied whether NFG and FG have anti-nociceptive effect, using by calcium imaging and behavioral assessment.