Effects of acute arginine treatment on vascular endothelial dysfunction associated with ischemic acute kidney injury.

Keisuke Nakagawa,Ayaka Shimomura, Atsuhiko Yamamoto,Shuhei Kobuchi,Mamoru Ohkita,Yasuo Matsumura

Proceedings for Annual Meeting of The Japanese Pharmacological Society（2020）

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Abstract

Background：It has been reported that the incidence of cardiovascular diseases were increased after acute kidney injury (AKI). On the other hand, there are few reports that evaluated vascular endothelial function underlying cardiovascular risk after AKI. We have previously confirmed that vascular endothelial function declines after AKI. This study, we examined the relationship between vascular endothelial dysfunction in AKI and indoxyl sulfate (IS) and NO bioavailability.

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Key words

ischemic acute kidney injury,acute arginine treatment,vascular endothelial dysfunction

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