Influence of ionizing radiation on development of thymus and thymocytes

Purpose: Among other reasons, the deteriorating global security situation and dangers associated with nuclear weapons have increased the need for deeper knowledge of the basic mechanisms involving the human immune system and ionizing radiation (IR).We conducted a review as to the effects of IR on thymic tissue, and particularly on the development of thymocytes and the T lymphocytes population in peripheral blood.Existing knowledge on this topic is based in part on national registers that store records concerning irradiated people.The majority of studies in this area, however, are based on experimental animal models.The main open question in this subject area regards the delayed effects of IR on thymus tissue, development of thymocytes, and subsequent impact on the immune system.Findings acquired to date on effects of IR are contributing to emerging fields such as immunotherapy, the objective of which is to support or activate natural immunity response.Methods: Recent research articles were reviewed regarding the influence of IR on thymus tissue and thymocytes development.Results: Differentiation and proliferation of thymocytes constitute a complex and sensitive process that is partially altered after irradiation, as are, too, the mechanisms for movement of early (derived from bone marrow) and derived (thymus derivatives) precursors.Disruption of these processes may lead to alteration of immune system function.Conclusions: Low doses (<200 mGy) may lead to changes in or disruption of functions of the thymus, thymocytes, and mechanisms of the immune system.The extent of IR's influence is dependent not only on the individual's radiosensitivity but also on his or her sex and age.With increasing absorbed IR dose, the risk of damage to thymus tissue and thymocytes in the organism rises and the extent of damage increases.