Prepubertal Serum Organochlorine Pesticide Concentrations and Growth among Russian Boys

Prepubertal Serum Organochlorine Pesticide Concentrations and Growth among Russian BoysAbstract Number:2031 Jane Burns*, Paige Williams, Oleg Sergeyev, Mary Lee, Susan Korrick, Boris Revich, Thuy Lam, and Russ Hauser Jane Burns* Harvard School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author , Paige Williams Harvard School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author , Oleg Sergeyev Chapaevsk Medical Association, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Mary Lee University of Massachusetts Medical Center, United States, E-mail Address: [email protected] Search for more papers by this author , Susan Korrick Brigham and Women's Hospital, United States, E-mail Address: [email protected] Search for more papers by this author , Boris Revich Russian Academy of Sciences, Russian Federation, E-mail Address: [email protected] Search for more papers by this author , Thuy Lam Harvard School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author , and Russ Hauser Harvard School of Public Health, United States, E-mail Address: [email protected] Search for more papers by this author AbstractObjective. We assessed associations of prepubertal serum organochlorine pesticides (OCPs: hexachlorobenzene [HCB], ß-hexachlorocyclohexane [ß-HCH], and p,p'-dichlorodiphenyldichloroethylene [DDE]) with pubertal growth among boys in Chapaevsk, Russia, a city with environmental OCP contamination.Methods. We prospectively followed 350 boys enrolled at ages 8-9 years from 2003-2005 for 8 years in a cohort study of environmental exposures, growth and puberty. At study entry, blood was drawn for OCP measurement and guardians completed questionnaires to ascertain medical history, socioeconomic status (SES), and diet. Annual physical exams included pubertal status, height and weight measurements, from which WHO body mass index (BMIZ) and height (HTZ) z-scores were calculated. Associations of lipid-adjusted OCP quintiles with longitudinal BMIZ and HTZ were examined by multivariable linear regression models for repeated measures.Results. The OCP ranges were 31-2660, 39-2860, 48-9370 ng/g lipid for HCB, ß-HCH, and DDE, respectively. At ages 16-17 years, the mean (SD) for BMIZ was -0.27 (1.26) and for HTZ was 0.20 (0.93). Over 8 follow-up years, in models adjusted for age, birth weight and prematurity, pubertal status, SES, blood lead levels, and nutritional factors, boys in the highest quintile of OCPs compared with the lowest had significantly lower BMIZ (HCB: -0.89, 95% CI -1.25, -0.53; ß-HCH: -1.32, 95% CI -1.67, -0.97; DDE: -1.26, 95% CI -1.62, -0.91). The highest quintile of DDE was associated with significantly lower HTZ (-0.41, 95% CI -0.72, -0.14).Conclusion. In this Russian boys’ cohort, higher prepubertal OCPs were associated with lower BMIZ and higher DDE was associated with lower HTZ. These results confirm growth associations reported previously in short-term follow-up of the same cohort and verify that these findings are not likely due to reverse causation. Funded by EPA Grant R82943701, NIEHS Grants ES014370, ES000002 & ES017117.