A Randomized Controlled Trial of HEPA Filter Air Cleaner Use and Fetal Growth in Ulaanbaatar, Mongolia
ISEE Conference Abstracts(2016)
摘要
Introduction: Fine particulate matter (PM2.5) exposures may impair fetal growth. We conducted a randomized controlled trial to assess the efficacy of portable HEPA filter air cleaners to reduce fetal growth restriction among non-smoking pregnant women in Ulaanbaatar, Mongolia, where residential coal use leads to high ambient PM2.5 concentrations. Methods: We randomly assigned 540 women to an intervention (1-2 air cleaners) or control (no air cleaners) group. One-week continuous PM2.5 measurements were made at approximately 12 and 30 weeks gestation. Housing, maternal health, and birth outcome (weight, length, head circumference, and gestational age) data were obtained via questionnaires and clinical records. We used linear regression to examine the efficacy of the intervention on birth outcomes for all live births (n=463) and term births (n=424), adjusting for gestational age, sex and parity, in an intention-to-treat analysis. Results: Based on 690 PM2.5 measurements, the geometric mean (GSD) concentration was 26 % lower in intervention homes [35 (2) vs. 47 (2) µg/m3]. The mean (SD) birth weight, birth length, and head circumference were 3457 (545) g, 51 (3) cm, and 35 (2) cm, respectively, among all live births and there were no differences by group assignment. In adjusted models of all births, the intervention did not result in a significant difference in birth weight (49 g; 95% CI: -27, 125 g; p=0.20), birth length (0.2 cm; 95% CI: -0.2. 0.6 cm; p=0.24), or head circumference (0.1 cm; 95% CI: -0.2, 0.4 cm; p=0.67). Among term births, the intervention resulted in a marginally significant increase in birth weight [68 g (95% CI: -5, 142 g; p=0.07] and a 0.4 cm increase in birth length (95% CI: 0.04, 0.7 cm; p=0.03). Conclusion: HEPA filter air cleaner use during pregnancy in this high pollution setting is associated with improved fetal growth as indicated by greater birth length and birth weight among term births.
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关键词
fetal growth
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