Zebrafish as a model for hypophosphatasia

Hypophosphatasia (HPP) is a rare hereditary disease due to mutations in the tissue-nonspecific alkaline phosphatase (TNAP) gene. HPP leads to severe dental and bone mineralization issues, craniosynostosis, and neurological disorders like epileptic seizures, anxiety, and depression. We established the zebrafish (Danio rerio) as in vivo model system for detailed investigations and visualization of tissue-specific effects in the context of craniosynostosis and neuronal symptoms of HPP.