Usefulness of P16 and KI67 Immunostaining in Cervical Smear Cytology in Guatemalan Women: A Cross-Sectional Study

Conventional cytology is an economic method for screening abnormalities in cervical smears, but with implications in false positive and false negative as compared to better detection of transformed cells with the Dual staining P16/KI67 proteins in cervical smears, therefore, we evaluate the validity and reproducibility of cytology with double staining of P16 and KI67 as compared to conventional cytology in cervical smears.