XXIII Международный симпозиум Нанофизика и наноэлектроника", Нижний Новгород, 11-14 марта 2019 г. Сравнительное исследование полимерных наночастиц на основе смесей поликапролактона и поливинилового спирта с инкапсулированным противоопухолевым препаратом методами атомно-силовой микроскопии, рентгеновской дифракции и динамического рассеяния света

Using the methods of atomic force microscopy, optical microscopy, X-ray diffraction analysis, dynamic and static light scattering, we studied the morphology, structure, and optical properties of compositions based on biodegradable polymer nanoparticles prepared from mixtures of polycaprolactone and a stabilizer - polyvinyl alcohol containing the antitumor preparation 5-fluorouracil. Studies have shown significant changes in the morphology of the resulting compositions depending on the stabilizer content. No crystalline reflections corresponding to 5-fluorouracil were found, which indicates a high degree of the drug dispersion in the polycaprolactone polymer matrix. Correlations between structural and morphological parameters, composition, stabilizer concentration and encapsulation efficiency of the 5-fluorouracil drug in the compositions have been established.