P4-090: nia genetics of alzheimer's disease data storage site (niagads): update 2019

NIAGADS is a national genetics data repository that facilitates access of genotypic data to qualified investigators for the study of the genetics of late-onset Alzheimer's disease (AD) and other neurological diseases. Collaborations with large consortia and centers such as the Alzheimer's Disease Genetics Consortium (ADGC), Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Alzheimer's Disease Genome Sequencing Project (ADSP), and the Genome Center for Alzheimer's Disease (GCAD) allow NIAGADS to lead the effort in managing large AD datasets that can be easily accessed by the research community and utilized to their fullest extent. NIAGADS is supported by National Institute on Aging (NIA) under a cooperative agreement (U24 AG041689). All data derived from NIA funded AD genetics studies are expected to be deposited in NIAGADS or another NIA approved site. NIAGADS recently developed its Data Sharing Service (DSS) that facilitates the deposition and sharing of genomic data and association results with approved users in the neurodegenerative research community. In addition, researchers are able to freely use the NIAGADS Genomics Database to search annotation resources that link published AD studies to AD-relevant sequence features and genome-wide annotations. As of January 2019, NIAGADS houses 45 datasets (11 added in 2018) with >45,000 samples and over 30 billion genotypes. With the completion of the Discovery and Extension phases of ADSP, qualified investigators can retrieve sequencing data with ease and flexibility through the new NIAGADS Data Sharing Service (DSS). The ADSP project has completed whole exome sequencing of 10,939 subjects and whole-genome sequencing of 3,952 subjects. Raw ADSP whole exome and whole genome data, including data from Alzheimer's Disease Neuroimaging Initiative (ADNI), on GrCh38 and quality controlled VCF files are via qualified access. Planned datasets for 2019 include a large whole-exome and whole-genome project level VCF. NIAGADS is a rich resource for AD researchers, with the goal of facilitating advances in Alzheimer's genetics research. By housing datasets from multiple projects and institutions, NIAGADS enables AD researchers to be more efficient in meeting their research goals. Datasets, guidelines, and new features are available on our website at https://www.niagads.org.