The relation between the RANKL and resistin in menopausal women with osteoporosis
THE 7TH INTERNATIONAL CONFERENCE ON APPLIED SCIENCE AND TECHNOLOGY (ICAST 2019)AIP Conference Proceedings(2019)
Abstract
Osteoporosis (OP) is osteometabolic disease characterized by a decrease in bone mineral density(BMD) and due to the deterioration of bone architecture leading to spontaneous fractures. The aim of the current study is to evaluate the biomarkers include the; receptor activator of nuclear factor NF-κB ligand and Resistin, also measuring the biochemical include: estrogen, calcium, phosphorus, bone mineral density, t-scores in menopausal women with osteoporosis, and further more study the correlation between these biomarkers and biochemical. Method : This study was conducted at DEXA (dual-energy x-ray absorptiometry) Unit in Radiology Department in Al-Sader teaching hospital in AL-Najaf province /Iraq from January2018 to July 2018 to know the prevalence of osteoporosis in Iraqi menopausal women. A total of the (88) women involved in this study, blood samples had been taken from the (68) osteoporosis menopausal women, and from (20) women who were apparently healthy as a control group. Assays of study estimation of the parameters levels that include: Calcium, phosphorous were done by using auto biochemistry analyzer; Receptor activator of nuclear factor NF-κB ligand bone alkaline phosphatase, Resistin and estrogen, were measurement by using a solid phase enzyme-linked immunosorbent assay (ELISA). Result: The result of study showed a significant decrease (p < 0.05) in concentration of serum estrogen, calcium and phosphorus in menopausal women with osteoporosis compared with healthy group. The biomarker revealed a significant increase (p < 0.05) in the concentration of receptor activator of nuclear factor NF-κB ligand and Resistin in menopausal women with osteoporosis compared with healthy group. The study exhibited correlation coefficient and showed a significant (p < 0.05) negative correlation between BMD and receptor activator of nuclear factor NF-κB ligand. The study showed a significant negative (p < 0.05) correlation between estrogen and of nuclear factor NF-κB ligand. This study show significant (p < 0.05) positive correlation of receptor activator of nuclear factor NF-κB ligand with resistin.
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Key words
Bone Mineral Density,Osteoblast Differentiation,Osteoporotic Fractures,Bone Resorption,Osteoclast Differentiation
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