Synthesis and biological evaluation of potent benzoselenophene and heteroaromatic analogues of (S)-1-(chloromethyl)-8-methoxy-2,3-dihydro-1H-benzo[e]indol-5-ol (seco-MCBI)

Amol B. Mhetre, Eppakayala Sreedhar,Rashmi Dubey,Ganesh A. Sable, Hangeun Lee,Heekyoung Yang,Kyoungmin Lee,Do-Hyun Nam,Dongyeol Lim

RSC Advances（2019）

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摘要

Incorporation of a methoxy substituent at the C-7 position of CBI and N-amido substitution at the C-5 position of benzoselenophene significantly enhances the anticancer activity of duocarmycin analogs.

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