Vitamin D and Hepatitis C Virus-relatedLiver Disease

Vitamin D through the vitamin D receptor (VDR) is involved in the control of bone and calcium homeostasis, immunoregulation, cellular differentiation,and anti-inflammatoryactions.The liver is central in vitamin D synthesis, however the direct involvement ofthe vitamin D with chronic liver disease, chronic hepatitis C (CHC) infection, and hepatocellular carcinoma (HCC) remains to be evaluated.The purpose of thisreview is to describevitamin D metabolism, the mechanisms of homeostatic control, and to address the associationsbetween vitamin D and HCV-related liver disease.