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Synthesis of Enantiomeric Halolactones with Aromatic Ring, Their Anticancer Activity and Interactions with Biological Membranes

Witold Gładkowski,Aleksandra Pawlak,Aleksandra Włoch,Marcelina Mazur,Halina Kleszczyńska,Bożena Obmińska-Mrukowicz

Proceedings（2019）

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Abstract
Studying the effect of chirality on the activity of tested compounds, we synthesized new series of the enantiomeric (ee = 98–100%) β-aryl-δ-halo-γ-lactones with defined configurations of stereogenic centers. [...]
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Key words
lactones, enantiomers, lipase, antiproliferative activity, interactions with membranes
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