The clinical efficacy of BTK inhibitors in the treatment of CLL v1

Studies of BTK as a target have enjoyed substantial popularity among the researcher circle ever since its role in B-cell maturation as well as in mast cell activation through the high-affinity IgE receptor have been confirmed, which given rise to the development of a diverse array of BTK inhibitors. Ibrutinib and Acalabrutinib are two BTK inhibitors that have already been approved for clinical use, while there are many other BTK inhibitors with published structures, such as Olmutinib, Tirabrutinib, Spebrutinib and more. CLL is the most common type of leukemia in adults. In the United States, it accounts for a quarter of the total number of new leukemia patients. Excessive hematopoietic stem cells in the bone marrow of CLL patients produce abnormal lymphocytes, and these abnormal cells do not normally fight infection. An increase in the number of abnormal cells simultaneously reduces the production of normal white blood cells, red blood cells, and platelets. This can lead to anemia, infection and bleeding. The BTK-mediated B cell receptor signaling pathway is an important signaling pathway for stimulating CLL growth. Calquence can inhibit BTK activity by covalent binding to BTK. The new drug has been approved by the FDA in 2017 for the treatment of adult patients with mantle cell carcinoma (MCL) who have received a pre-treatment.