Mp66-16 clinical significance of multiparametric mri and psa density as predictors of residual tumor (pt0) following radical prostatectomy for t1a-t1b (incidental) prostate cancer

You have accessJournal of UrologyProstate Cancer: Localized: Surgical Therapy V (MP66)1 Apr 2019MP66-16 CLINICAL SIGNIFICANCE OF MULTIPARAMETRIC MRI AND PSA DENSITY AS PREDICTORS OF RESIDUAL TUMOR (PT0) FOLLOWING RADICAL PROSTATECTOMY FOR T1A-T1B (INCIDENTAL) PROSTATE CANCER Doo Yong Chung*, Jong Soo Lee, Won Sik Jang, In Rae Cho, Young Sig Kim, Joong Shik Lee, Dong Hoon Lim, Don Gu Lee, Jin Hyung Jeon, Hyun Ho Han, Won Sik Ham, and Young deuk Choi Doo Yong Chung*Doo Yong Chung* More articles by this author , Jong Soo LeeJong Soo Lee More articles by this author , Won Sik JangWon Sik Jang More articles by this author , In Rae ChoIn Rae Cho More articles by this author , Young Sig KimYoung Sig Kim More articles by this author , Joong Shik LeeJoong Shik Lee More articles by this author , Dong Hoon LimDong Hoon Lim More articles by this author , Don Gu LeeDon Gu Lee More articles by this author , Jin Hyung JeonJin Hyung Jeon More articles by this author , Hyun Ho HanHyun Ho Han More articles by this author , Won Sik HamWon Sik Ham More articles by this author , and Young deuk ChoiYoung deuk Choi More articles by this author View All Author Informationhttps://doi.org/10.1097/01.JU.0000556948.84535.57AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVES: The aim of this study was to evaluate predictors of residual tumor and clinical prognosis in T1a-T1b (incidental) prostate cancer by analysis of specimens from men undergoing surgery for benign prostatic hyperplasia. METHODS: We retrospectively reviewed medical records of incidental prostate cancer patients who had undergone radical prostatectomy. Patients whose tumor statuses were further confirmed by prostate biopsy, or who had used androgen deprivation therapy before radical prostatectomy, were excluded. Clinical and pathological parameters were analyzed to evaluate residual tumor and clinical prognosis. We used univariate and multivariate logistic regression analyses, as well as receiver operator characteristics, to predict residual tumor (pT0). RESULTS: The final analysis included 95 patients. Among these patients, 67 (70.53%) exhibited residual tumor, whereas 28 (29.47%) did not (pT0). Pathology findings showed that 44 (65.67%), 16 (23.88%), and 7 patients (10.45%) exhibited Gleason scores of G6, G7, and ≥G8, respectively. Fifty-seven and 10 patients exhibited pathologic T stages T2 and T3, respectively. Mean follow-up duration was 70.26 (±34.67) months. Biochemical recurrence was observed in 11 patients; none were pT0 patients. Multivariate logistic regression showed that low prostate-specific antigen density after benign prostatic hyperplasia surgery and invisible lesion on multiparametric magnetic resonance imaging were significantly associated with pT0. Additionally, a combination of these factors showed an increase in the diagnostic accuracy of pT0, compared with mpMRI alone (AUC 0.805, 0.767, respectively); this combination showed sensitivity, specificity, and positive predictive values of 71.6%, 89.3%, and 94.1%, respectively. CONCLUSIONS: Our results suggest that patients with incidental prostate cancer who have both prostate-specific antigen density ≤0.08 after benign prostatic hyperplasia surgery as well as invisible cancer lesion on multiparametric magnetic resonance imaging should be considered for active surveillance. Source of Funding: none Seoul, Korea, Republic of; Gimhae, Korea, Republic of; Goyang, Korea, Republic of; Seoul, Korea, Republic of; Gwangju, Korea, Republic of; Seoul, Korea, Republic of© 2019 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 201Issue Supplement 4April 2019Page: e964-e965 Advertisement Copyright & Permissions© 2019 by American Urological Association Education and Research, Inc.MetricsAuthor Information Doo Yong Chung* More articles by this author Jong Soo Lee More articles by this author Won Sik Jang More articles by this author In Rae Cho More articles by this author Young Sig Kim More articles by this author Joong Shik Lee More articles by this author Dong Hoon Lim More articles by this author Don Gu Lee More articles by this author Jin Hyung Jeon More articles by this author Hyun Ho Han More articles by this author Won Sik Ham More articles by this author Young deuk Choi More articles by this author Expand All Advertisement PDF downloadLoading ...