Challenges of Recruitment to Interventional MSK Oncology in Palliative Care – Focus on MRI Guided High Intensity Focused Ultrasound (MRg-HIFU) for Treating Skeletal Metastasis

Purpose: New innovations in musculoskeletal interventional oncology need validation and evidence to develop the most effective treatment options, pathways, and guidelines, thus optimizing outcomes and quality of life for patients, even more so for those in palliative care. Obstacles in patient recruitment exist in all trials, but the reasons for nonparticipation are less well understood. We reflect on our experience in magnetic resonance guided high-intensity focused ultrasound (MRg-HIFU) therapy of skeletal metastasis and correlate it with the current literature.