Highly-Controllable Imprinted Polymer Nanoshell on the Surface of Silica Nanoparticles for Selective Adsorption of 17<i>β</i>-Estradiol

A highly-controllable core-shell silica-MIPs absorbent by anchoring a MIPs layer to the surface of SiO 2 nanoparticles via a surface molecular imprinting process was prepared.The templates were covalently modified with functional monomers to form precursor EstSi.The latter together with coupling reagent KH-570, were grafted onto the surface of SiO 2 nanoparticles before polymerization, to ensure the quantity and quality of imprinted sites on the surface of the covalently attached matrix.The as-synthesized core-shell nanomaterials (SiO 2 @MIP2) were then evaluated for selective adsorption of 17β-estradiol (E2) with Raman spectra as detection method.The results indicate that SiO 2 @MIP2 can fast and selectively adsorb E2 from structural analogues, with detection limit of 0.01 μmol/l.